Bivalent metal complexes of a novel modified nicotinic acid hydrazide drug: Synthesis, characterization, and anti-tubercular studies

Iron(II) and manganese(II) complexes of N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (LH) have been synthesized characterized by elemental analysis, IR, 1H NMR spectroscopy. The crystal structure the ligand has determined single X-ray diffraction electronic spectroscopic techniques. Crystal data for LH, C13H12N4O: Orthorhombic, space group Pbcn (no. 60), a = 18.0824(3) Å, b 7.86555(14) c 16.1614(3) V 2298.60(7) Å3, Z 8, T 103 K, μ(Mo Kα) 0.093 mm-1, Dcalc 1.388 g/cm3, 36729 reflections measured (5.042° ≤ 2Θ 54.966°), 2633 unique (Rint 0.0224, Rsigma 0.0124) which were used in all calculations. final R1 was 0.0383 (F2>2σ(F2)) wR2 0.0988 (all data). found to chelate metal ions through azomethine nitrogen amide oxygen atoms bidentate manner. anti-tubercular activity ligand, its iron (II) manganese studied against Mycobacterium tuberculosis (ATTC 27294). results revealed higher complex with MIC value 8.00±0.83 µM moderate having 14.20±1.40 µM, compared reference drugs values 9.41±0.92, 10.74±1.02, 25.34±2.6 parent 17.60±1.80 µM.